There is a direct correlation between marijuana and depression symptoms, as studies show that marijuana smokers are significantly more likely to suffer from depression than non-smokers. But how this mechanism works, or whether there is a mechanism at all, remains debatable.
For example, if we diagnose more marijuana users with depression symptoms, it could simply mean that depressed people use marijuana. In addition, marijuana contains hundreds of active compounds, so it is not always entirely clear how such a mechanism works.
However, researchers studying the link between marijuana and depression symptoms know how it might work.
Simply put, the brain uses chemicals to transmit information between neurons.
These chemicals are called neurotransmitters. Among them are glutamate, gamma-amino-butyric acid (gaba), acetylcholine, etc. When a person uses marijuana, these neurotransmitters are extremely depleted. Many studies have shown that it directly related the depletion of neurotransmitters in the brain to depression, which could be the link between marijuana and depression.
Marijuana depletes neurotransmitters, so when a person comes out of their high, they become extremely depressed.
Even worse, people who are already depressed use marijuana.
When the drug further depletes their neurotransmitters, the cycle of depression symptoms worsens. When the person comes out of the euphoria of marijuana, they are even more depressed than they were before taking the drug.
This makes them want to use marijuana again as quickly as possible, which further depletes their neurotransmitters... and makes the depression symptoms even worse. There is hard data showing that marijuana use causes this cycle of depression to get worse and worse.
There is evidence that marijuana in tiny amounts can reduce the elements of depression symptoms. But in high doses, it makes the depression worse. What is troubling is that the THC in marijuana available today is several times stronger than the THC in marijuana available twenty or thirty years ago.
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This high THC content means that modern marijuana is much more depressing than the marijuana used, for example, in the 1980s.
Marijuana users should stick to a low dose if they want to avoid the depressive qualities of the drug. Heavy or prolonged use is not recommended, as no studies show what happens to the mind when neurotransmitters are chronically depleted over a long period.
However, such prolonged use has been linked to a significant decline in mental acuity and serious memory problems. Some research suggests that this may be because of the brain losing some of its ability to form new synaptic chains.depression and anxiety
